SER-CAT Outstanding Science Award


 


The SER-CAT Science Committee is offering an award for Outstanding Science supported by SER-CAT data published in the past calendar year. The Outstanding Science Award is open to any researcher or…

Immunogenicity and therapeutic targeting of a public neoantigen derived from mutated PIK3CA.





Public neoantigens (NeoAgs) represent an elite class of shared cancer-specific epitopes derived from recurrently mutated…

Structure of the catalytically active APO-BEC3G bound to a DNA oligonucleotide inhibitor reveals tetrahedral geometry of the transition state


The 2023 SER-CAT Outstanding Science Award was presented to Dr. Hiroshi Matsuo…

Molecular mechanism regulating transcriptional control of the hig toxin‐antitoxin locus of antibiotic-resistance plasmid Rts1 from Proteus vulgaris


The 2022 SER-CAT Young Investigator Award was presented to Dr. Ian Pavelich…

Zika-specific neutralizing antibodies targeting inter-dimer envelope epitopes.


Zika virus (ZIKV) is an emerging pathogen that causes devastating congenital defects. The overlapping epidemiology and immunologic cross-reactivity…

Specific inhibition of an anticancer target, polo-like kinase 1, by allosterically dismantling its mechanism of substrate recognition.


Polo-like kinase 1 (Plk1) is considered an attractive target for anticancer therapy. Over the…

A human antibody epitope map of the malaria vaccine antigen Pfs25.


Pfs25 is a leading antigen for a malaria transmission-blocking vaccine and shows moderate transmission-blocking activity and induction of rapidly decreasing antibody…

Zinc-finger BED domains drive the formation of the active Hermes transpososome by asymmetric DNA binding.


The Hermes DNA transposon is a member of the eukaryotic hAT superfamily, and its transposase forms a ring-shaped tetramer of…

Structure of anhydrotetracycline‐bound Tet(X6) reveals the mechanism for inhibition of type 1 tetracycline destructases.



  • Authors: Hirdesh Kumar, Emily E Williford, Kevin S Blake, Brett Virgin-Downey,…

Regions of hepatitis C virus E2 required for membrane association.



  • Authors: Ashish Kumar, Tiana C Rohe, Elizabeth J Elrod, Abdul G Khan, Altaira D Dearborn, Ryan Kissinger, Arash Grakoui,…

Structural characterization of protective non‐neutralizing antibodies targeting Crimean‐Congo hemorrhagic fever virus.



  • Authors: Ian A Durie, Zahra R Tehrani, Elif Karaaslan, Teresa E Sorvillo, Jack McGuire, Joseph W Golden,…

Structure of the catalytically active APOBEC3G bound to a DNA oligonucleotide inhibitor reveals tetrahedral geometry of the transition state.



  • Authors: Atanu Maiti, Adam K Hedger, Wazo Myint, Vanivilasini Balachandran, Jonathan…