Outstanding Science Awards

Dr. Brian M. Baker

Immunogenicity and therapeutic targeting of a public neoantigen derived from mutated PIK3CA

Authors: Smita S Chandran, Jiaqi Ma, Martin G Klatt, Friederike Dundar, Chaitanya Bandlamudi, Pedram Razavi, Hannah Y Wen, Britta Weigelt, Paul Zumbo, Si Ning Fu, Lauren B Banks, Fei Yi, Enric Vercher, Inaki Etxeberria, Watchain D Bestman, Arnaud Da Cruz Paula, Ilinca S Aricescu, Alexander Drilon, Doron Betel, David A Scheinberg, Brian M Baker, Christopher A Klebanoff.

Abstract: Outstanding Science Award (2022)

Previous Years Outstanding Science:

• 2021 - Endogenous DNA 3' Blocks Are Vulnerabilities for BRCA1 and BRCA2 Deficiency and Are Reversed by the APE2 Nuclease;

  • Authors: Authors: Alejandro Alvarez-Quilon, Jessica L Wojtaszek, ..., R Scott Williams, Daniel Durocher.

     

• 2020 - A Small Molecule Targeting Mutagenic Translesion Synthesis Improves Chemotherapy;

  • Authors: Authors: Jessica L Wojtaszek, Nimrat Chatterjee, Javaria Najeeb, ..., Michael T Hemann, Jiyong Hong, Graham C Walker, Pei Zhou.

     

• 2020 - Trispecific antibodies enhance the therapeutic efficacy of tumor-directed T cells through T cell receptor co-stimulation;

  • Authors: Lan Wu, Edward Seung, ..., Zhi-yong Yang, Gary J. Nabel.

     

• 2019 - Crystal Structure of the Labile Complex of IL‐24 with the Extracellular Domains of IL‐22R1 and IL‐20R2;

  • Authors: Lubkowski J, Sonmez C, Smirnov SV, Anishkin A, Kotenko SV, Wlodawer A.

     

• 2018 - Visualizing Multistep Elevator-like Transitions of a Nucleoside Transporter;

  • Authors: Marscha Hirschi, Zachary Lee Johnson, Seok-Yong Lee.

     

• 2017 - Observing cellulose biosynthesis and membrane translocation in crystallo;

  • Authors: Jacob L. W. Morgan, Joshua T. McNamara, ..., Jochen Zimmer.

     

• 2016 - Crystal Structure of Human Glycine Receptor-α3 Bound to Antagonist Strychnine;

  • Authors: Xin Huang, Hao Chen, Klaus Michelsen, Stephen Schneider, Paul L. Shaffer.

     

• 2015 - Structure of a Naegleria Tet-like Dioxygenase in Complex With 5-methylcytosine DNA;

  • Authors: Hideharu Hashimoto, June E Pais, ..., Yu Zheng, Xiaodong Cheng.

     

• 2014 - Observing a DNA Polymerase Choose Right from Wrong;

  • Authors: Bret D. Freudenthal, William A. Beard, David D. Shock, Samuel H. Wilson.

     

• 2013 - Structural Basis for Iron Piracy by Pathogenic Neisseria;

  • Authors: Nicholas Noinaj, Nicole C. Easley, ..., Susan K. Buchanan.

     

• 2012 - Structure of HIV-1 gp120 V1/V2 Domain with Broadly Neutralizing Antibody PG9;

  • Authors: Jason S. McLellan, Marie Pancera, ..., Peter D. Kwong

     

• 2011 - G domain Dimerization Controls Dynamin’s Assembly-stimulated GTPase Activity;

  • Authors: Joshua S. Chappie, Sharmistha Acharya, Marilyn Leonard, Sandra L. Schmid, Fred Dyda.

     

• 2010 - Structure of ERA in Complex with the 3′end of 16SrRNA: Implications for Ribosome Biogenesis;

  • Authors: Chao Tu, Xiaomei Zhou, ..., Xinhua Ji.

     

• 2009 - Midbody Targeting of the ESCRT Machinery by a Noncanonical Coiled Coil in CEP55;

  • Authors: Hyung Ho Lee, Natalie Elia, Rodolfo Ghirlando, Jennifer Lippincott-Schwartz, James H. Hurley.

     

• 2008 - Structural Basis for Transcription Elongation by Bacterial RNA Polymerase;

  • Authors: Dmitry G Vassylyev, Marina N Vassylyeva, ... Irina Artsimovitch.

     

• 2008 - Structural Basis for Substrate Loading in Bacterial RNA Polymerase;

  • Authors: Dmitry G Vassylyev, Marina N Vassylyeva, ..., Robert Landick.

     

• 2007 - Outer Membrane Active Transport: Structure of the BtuB:TonB Complex;

  • Authors: David D Shultis, Michael D Purdy, Christian N Banchs, Michael C Wiener.

     

• 2006 - Role of Active Site Water Molecules and Substrate Hydroxyl Groups in Oxygen Activation by Cytochrome P450 158A2: A New Mechanism of Proton Transfer;

  • Authors: Bin Zhao, F Peter Guengerich, Markus Voehler, Michael R Waterman.

     

• 2005 - Error-prone Replication of Oxidatively Damaged DNA by a High-Fidelity DNA Polymerase;

  • Authors: Gerald W Hsu, Matthias Ober, Thomas Carell, Lorena S Beese.