Young Investigator Awards

Dr. Ian Pavelich

Molecular mechanism regulating transcriptional control of the hig toxin‐antitoxin locus of antibiotic-resistance plasmid Rts1 from Proteus vulgaris

Authors: Ian Pavelich, Marc A. Schureck, Dongxue Wang, Eric D. Hoffer, Michelle Boamah, Nina Onuoha, Stacey J. Miles, C. Denise Okafor, Christine M Dunham.

Previous Years Young Investigator:

• 2021 - Disruption of evolutionarily correlated tRNA elements impairs accurate decoding;

  • Authors: Ha An Nguyen, S Sunita, Christine M Dunham.

     

• 2019 - Drug Resistance Mutation L76V Alters Nonpolar Interactions at the Flap‐Core Interface of HIV‐1 Protease;

  • Authors: Andres Wong-Sam, Yuan-Fang Wang, Ying Zhang, Arun K Ghosh, Robert W Harrison, Irene T Weber.

     

• 2019 - Structural Insights of Stereospecific Inhibition of Human Acetylcholinesterase by VX and Subsequent Reactivation by HI‐6;

  • Authors: Bester SM, Guelta MA, ..., Pegan SD, Height JJ.

     

• 2018 - Tethering Not Required: The Glucocoricoid Receptor Binds Directly to Activator Protein-1 Recognition Motifs to Repress Inflammatory Genes;

  • Authors: Emily R. Weikum, Ian Mitchelle S. de Vera, ..., Eric A. Ortlund.

     

• 2017 - Oxygen activation at the active site of a fungal lytic polysaccharide monooxygenase;

  • Authors: William B O'Dell, Pratul K Agarwal, Flora Meilleur.

     

• 2016 - Defining the mRNA recognition signature of a bacterial toxin protein;

  • Authors: Marc A. Schureck, Jack A. Dunkle, Tatsuya Maehigashi, Stacey J. Miles, Christine M. Dunham

     

• 2014 - Structure of the Integral Membrane Protein CaaX ProteaseSte24p;

  • Authors: Edward E Pryor Jr, Peter S Horanyi, ..., Michael C Wiener, Mark E Dumont.

   

• 2013 - Repair of 5'-topoisomerase II-DNA adducts by mammalian tyrosyl-DNA phosphodiesterase 2;

  • Authors: Matthew J Schellenberg, C Denise Appel, ..., R Scott Williams.

   

• 2012 - Structural basis for RNA recognition by NusBand NusE in the initiation of transcription antitermination;

  • Authors: Jason R. Stagno, Amanda S. Altieri, ..., Xinhua Ji.

     

• 2011 - Crystal Structure of the Phage T4 RecombinaseUvsX and Its Functional Interaction with theT4 SF2 Helicase UvsW;

  • Authors: Stefan Gajewski, Michael R. Webb, ..., Kenneth N. Kreuzer, Stephen W. White.

   

• 2009 - Structural basis for executioner caspase recognition of P5 positionin substrates;

  • Authors: Guoxing Fu, Alexander A Chumanevich, Johnson Agniswamy, Bin Fang, Robert W Harrison, Irene T Weber.

     

• 2008 - Structure of Dnmt3a Bound to Dnmt3L Suggests a Model for De Novo DNA Methylation;

  • Authors: Da Jia, Renata Z. Jurkowska, Xing Zhang, Albert Jeltsch, Xiaodong Cheng.

     

• 2007 - Crystal Structure of the Geobacillus stearothermophilus Carboxylesterase Est55 and Its Activation of Prodrug CPT-11;

  • Authors: Ping Liu, Hosam E. Ewis, Phang C. Tai, Chung-Dar Lu, Irene T. Weber.

     

• 2006 - Structural Insight into the Mechanismof Double-Stranded RNA Processing by Ribonuclease III;

  • Authors: Jianhua Gan, Joseph E. Tropea, ..., Xinhua Ji.

   

• 2005 - Crystal Structure of A. fulgidus Rio2 Defines a New Family of Serine Protein Kinases;

  • Authors: Nicole LaRonde-LeBlanc, Alexander Wlodawer.