A human antibody epitope map of the malaria vaccine antigen Pfs25. Pfs25 is a leading antigen for a malaria transmission-blocking vaccine and shows moderate transmission-blocking activity and induction of rapidly decreasing antibody titers in clinical trials. A comprehensive definition of all transmission-reducing epitopes of Pfs25 will inform structure-guided design to enhance Pfs25-based vaccines, leading to potent transmission-blocking activity... Authors: Niharika Shukla, Wai Kwan Tang, Camila H Coelho, Carole A Long, Sara A Healy, Issaka Sagara, Kazutoyo Miura, Patrick E Duffy, Niraj H Tolia. NPJ Vaccines. 2023 Aug 4;8(1):108. doi: 10.1038/s41541-023-00712-z. Previous Science Highlights
